BIO-CAPPED SELENIUM NANOPARTICLES CONJUGATED WITH BOVINE SERUM ALBUMIN FOR TARGETED THERAPY (KEY IJP************628)

• Sangeetha P,Charumathi R,Santhaseelan C

Abstract

To perform the green synthesis of selenium nanoparticles capped with plant extract nanoparticles are nano-sized particles with the dimension ranging from 1-100 nm. The production of selenium nanoparticles typically employs one of three techniques: physical, chemical, or biological techniques. We can characterize the synthesized selenium nanoparticles through UV-visible Spectrophotometer, FT-IR, and XRD. After the characterization of selenium nanoparticles, they are bio-conjugated with bovine serum Albumin and determined the concentration of bovine serum albumin for bio-conjugation against the cancer cell lines. Finally molecular dynamic of bovine serum albumin-plant extract through bioinformatics tools using molecular docking. Green chemistry procedures emphasize the use of biological systems, which include microorganisms, and plant extract. Biological systems are used as capping, reducing, and stabilizing agents in replacement of chemical biogenic synthesis of selenium nanoparticles is nontoxic and economical and uses environmentally benign non-hazardous material such as phytochemicals from plant extracts.