REVIEW ON MUCOADHESIVE MICROSPHERES (KEY IJP************837)

• Karre Supriya,Kothuri Jyothi ,Ch. Shanthi Priya,S. Rohini Reddy

Abstract

Mucoadhesive microspheres have emerged as promising carriers for drug delivery due to their ability to adhere to mucosal surfaces, thereby prolonging residence time and enhancing therapeutic efficacy of various drugs, particularly those targeting mucosal surfaces. Microspheres constitute an important part of the novel drug delivery system by virtue of their small size and efficient carrying capacity. Due to their long residence time, bioadhesive characteristics mucoadhesion can be coupled to microspheres to develop mucoadhesive microspheres. Mucoadhesive Microspheres exhibit a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and thus contribute to improved and better therapeutic performance of drugs and also Mucoadhesive microspheres have advantages like efficient absorption and enhanced bioavailability of the drugs due to a high Surface to volume ratio, a much more intimate contact with the mucus layer, controlled and sustained release of drug from Dosage form and specific targeting of drugs to the absorption site. Mucoadhesive microspheres have been developed for oral, Buccal, nasal, ocular, rectal and vaginal for either systemic or local effects. It is an ideal targeting system with high safety Profile. This review article gives the information about mucoadhesion and theories of mucoadhesion. It also contains a number of available methods of preparation of mucoadhesive microspheres.