Beta lactam antibiotic (KEY IJP************927)

• Mayurgiri R. Gauswami ,Shweta V. Sankhat ,Jinal R. Kantariya ,Sakshi M. Rathod ,Ruhin M. Khokhar,Vruti M. Lumbhani

Abstract

-lactam antibiotics are a type of antibiotic that have a specific molecular structure called a -lactam ring. This group includes well-known antibiotics like penicillins, cephalosporins, carbapenems, and monobactams. They work by interfering with the synthesis of the bacterial cell wall, causing the bacteria to burst and die.However, over time, bacteria have developed ways to resist the effects of these antibiotics. One common resistance mechanism involves the production of enzymes called -lactamases. These enzymes break down the -lactam ring in the antibiotic molecules, rendering them ineffective against the bacteria.To combat this resistance, scientists have developed combination therapies that include -lactamase inhibitors along with the -lactam antibiotics. These inhibitors work by blocking the action of -lactamases, allowing the antibiotics to remain active and kill the bacteria effectively.