The study of the anti allergic activity of the natural products from marine source or organism (KEY IJP************232)

• Sumeet Ramdas Borchate

Abstract

Allergic diseases have become more common in recent years. affecting over 20% of the global population. The primary treatments for allergies today are topical corticosteroids and antihistamines, but these drugs can cause aduerse side effects and drug resistance with long-term use. This underscores the importance of finding alternative anti-allergic agents from natural sources. The unique conditions of the marine environment such as high pressure, low temperatures, and limited light-support the creation of highly functional and diverse natural products. This review discusses anti- allergia secondary metabolites with various chemical structures, including polyphenols, alkaloids, terpenoids, steroids, and peptides, primarily derived from fungi. bacteria, macroalgae, sponges, mollusks. and fish. It also employs molecular docking simulations using MOE to explore how some representative marine natural products may interact with the H1 receptor. This review provides valuable insights into the structures and anti-allergic activities of marine derived compounds, offering a useful reference for natural products. with immunomodulatory effects.