Nanosuspension Technology: A Promising Approach for Enhancing Drug Solubility and Bioavailability (KEY IJP************146)

• Pradeep M

Abstract

Pharmaceutical advancements have shown significant improvement through the innovation of nanosuspensions, colloidal dispersions, and biphasic drug particle systems in water with diameters smaller than 1 m. Increased surface area and saturation solubility of nanoscale drug particles lead to enhanced dissolution rates and bioavailability, especially for medications with low solubility in water or both water and fat. This review examines how nanosuspensions are made, their various applications, and their advantages, with a focus on their ability to be used for different methods of drug delivery like inhalation, eye drops, injections, and oral ingestion. New chemical entities (NCEs) with high log P values and melting points frequently present solubility challenges that cannot be adequately addressed by conventional techniques like micronization and co-solvent solubilization. On the other hand, nanosuspension technology provides a reliable solution using methods like emulsion diffusion, media milling, and high-pressure homogenization. The study compares the "top-down" and "bottom-up" methods in technology, highlighting the advantages of using high-pressure homogenization to create concentrated, stable nanosuspensions for different medical uses. Furthermore, an investigation is underway regarding the impact of stabilizers, surfactants, and co-surfactants on improving the physical stability and effectiveness of nanosuspensions. Factors like saturation solubility, zeta potential, crystalline state, and particle size distribution play a critical role in assessing the efficacy and stability of nanosuspension formulations. in conclusion, the development of new medications may find that using nanosuspensions is a feasible way to address problems with drug delivery, specifically those related to solubility and bioavailability. Their potential as a game-changing technology in the pharmaceutical sector is highlighted by their capacity to improve therapeutic efficacy and drug absorption.