FORMULATION AND EVALUATION OF LORNOXICAM SUSTAINED RELEASE TABLETS (KEY IJP************717)

• Pole Mounika, A. Siva Kumar, K. Jyothi, A. Yasodha

Abstract

In the present work, an attempt has been made to develop sustained release tablets of Lornoxicam by selecting Natural and synthetic polymers like Karaya Gum and HPMC K100 as retarding polymers. All the formulations were prepared by Wet granulation method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations L5 formulation showed maximum % drug release i.e., 99.56 % in 12 hours hence it is considered as optimized formulation L5 which contains HPMC K100 (8mg) . Whereas the formulations with HPMC K100 showed more retarding with less concentration of polymer. The formulations with Karaya gum were unable to produce the desired rug release pattern.