DESIGN AND EVALUATION OF PARACETAMOL CHEWABLE PAEDIATRIC ORAL JELLY (KEY IJP************218)

• Neha Kousar,Kandikatta Vaishnavi,Dolly Likhitha,Tupakula Navyasri,Prasanthi Raghavarapu,Tirunagari Mamatha

Abstract

This study aimed to formulate paracetamol in a new dosage form, jelly using gelatine and sucrose and to improve paediatric patients compliance to achieve maximum drug efficacy. Paracetamol is an antipyretic and analgesic, used in the treatment of pain and reduce a high temperature (fever). This dosage form was selected because of sharing between both advantages of liquid and solid dosage forms. A few liquid oral formulations are available in market containing 250 mg5 ml dose. However, as there is a chance of error in dosage of liquid oral formulations hence, an alternate, unit packaged oral jelly dosage from can be a very good option to get accurate dose. The effect of jellifying agents and their concentration have been investigated. It also has a pleasant texture and look, making it easy to attract and administer to patients. The organoleptic properties and physicochemical parameters (Such as - stickiness, texture, grittiness, drug content and pH) of the formulations were determined. The drug excipient compatibility study was done by FT-IR and was found that there is no physicochemical interaction. Dissolution studies have shown that more than 90 % drug is released within 10 min.