Hot Melt Extrusion in Pharmaceutics: A Modern Approach to Drug Formulation (KEY IJP************888)

• Ms. Revati Pramod Bhopale1,Ms. Devyani Satish Patil2,Mr. Damodar Avinash Dhangar3,Ms. Rutuja Kailas Patil4,Ms. Bhagyashri Dnyaneshwar Patil5,Ms. Ashwini Suresh Patil6

Abstract

Hot Melt Extrusion (HME) has emerged as a transformative technology in modern drug formulation, offering innovative solutions to long-standing challenges in the pharmaceutical industry. As a solvent-free, continuous manufacturing process, HME enhances the bioavailability of poorly water-soluble drugs through the formation of amorphous solid dispersions and enables the development of advanced dosage forms such as sustained-release tablets, transdermal systems, and implantable devices. Recent advancements in HME include the integration of twin-screw extruders, the co-extrusion of multi-layered drug delivery systems, and the incorporation of 3D printing for personalized medicine.