ADVANCEMENTS IN PHARMACOGENOMICS: IMPLICATIONS FOR PERSONALIZED MEDICINE AND CLINICAL PRACTICE (KEY IJP************142)

• Mr. Rohit Shivcharan Patil,Dr. Tabrej Mujawar,Mr. Ajay S. Jadhav,Ms. Pratiksha B. Patil,Ms. Swati S. Patil

Abstract

Pharmacogenomics, a branch of pharmacology, delves into how genetic variations influence patientsresponses to drugs by correlating gene expression or single-nucleotide polymorphisms with a drug's effectiveness or potential toxicity. Its objective is to devise logical methods to refine drug therapy based on a patient's genotype, aiming for optimal efficacy with minimal adverse effects. These methodologies herald the era of personalized medicine, wherein drugs and their combinations are tailored to the distinctive genetic makeup of each individual. Pharmacogenomics represents the comprehensive genomic application of pharmacogenetics, which primarily examines interactions between single genes and drugs.