DEVELOPMENT AND CHARACTERIZATION OF GASTRORETENTIVE FLOATING FILMS OF VILDAGLIPTIN FOR ENHANCED DIABETES MANAGEMENT (KEY IJP************367)

• Ankit Gosai Bhopaye,Nishan N. Bobade,Yukta Kashinath Mhaskey,Aditi Vijay Tikait

Abstract

This study developed gastroretentive floating films of Vildagliptin using various polymers (HPMC K4M, HPMC E4M, HPMC E5LV, and Hydroxyethyl cellulose) via solvent casting to enhance drug delivery for diabetes management. The formulations were extensively characterized for weight uniformity, thickness, folding endurance, swelling behavior, buoyancy, drug content, and in vitro dissolution profiles. Results demonstrated uniform weight distribution and adequate thickness across all formulations, ensuring consistent dosing. Films exhibited good flexibility and mechanical strength, with formulations containing HPMC K4M and HPMC E4M showing superior swelling indices, effective gastric retention, and controlled drug release. In vitro studies confirmed quick unfolding and prolonged floating times (8-11 hours), with formulations P8 and P2 achieving over 99% drug release in 9 hours. Fourier Transform Infrared Spectroscopy indicated polymer-drug compatibility, supporting their pharmaceutical viability. Overall, Vildagliptin-loaded floating films hold promise for improving diabetes therapy by enhancing drug delivery efficiency, extending gastric retention, and potentially improving patient adherence, suggesting future avenues for optimizing these formulations in clinical settings.Key Words: Gastroretentive drug delivery system (GRDDS); Floating Film; Solvent Casting Method; Controlled Release; Vildagliptin; Floating Film Drug Delivery System (FFDDS).