International Journal of Progressive Research in Engineering Management and Science
(Peer-Reviewed, Open Access, Fully Referred International Journal)

ISSN:2583-1062
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Paper Details

Ag-NPS WITH HUMAN SERUM ALBUMIN COATED PHYTO THERAPEUTIC AGENT CAPPED ACT AS A DRUGS DELIVERY AGAINST BREAST CANCER (KEY IJP************367)

  • Nithya Nataraj,Aaishabanu Matharshababu,Santhaseelan C

Abstract

Due to its ability to produce perfect release of drugs and biodistribution, drug delivery systems based on nanotechnology have recently attracted the interest of researchers in the field of nanomedicine. Due to their remarkable biological features and the availability of numerous different materials used to build drug delivery vehicles for effective cancer treatment, serum albumin-based nano vehicles have been extensively developed and explored. Human serum albumin is one of them and is a remarkably effective and promising carrier for an anti-cancer pharmaceutical. Long half-life, frequent recycling, and specific accumulation are the benefits of HSA. HSA has many binding pockets where various ligands, such as fatty acids and ions, can bind, providing pharmaceuticals with a variety of non-covalent binding sites. In addition, HSA has increased drug half-lives, decreased renal drug clearance, and increased drug accumulation in specific cancer tissues. HSA is an ideal chance to deliver widely used drugs in a brand-new way. Wrightia tinctoria leaves were used to create the plant alkaloid substance known as brucine. Silver nitrate was combined with brucine solution to synthesis silver nanoparticles. UV-vis Spectrophotometer, SEM, and FTIR were used to characterise nanoparticles. This review examined the bioconjugation of HSA with Phyto therapeutic agent-capped Ag-NPs. The ex-vivo approach was used to execute and evaluate human serum albumin as a drug delivery vehicle against the MCF-7 breast cancer cell line. Phyto therapeutic agent capped Ag-NPs coated with HSA may be used as a workable drug delivery system in the treatment of cancer, according to the results.

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