Evaluation of Nephroprotective activity of Ficus religiosa by Gentamicin in Wistar Rats (KEY IJP************669)

• Surbhi Jangir,Kamini Kumari,Prashant Kumar Dhakad

Abstract

Medicinal plants play a crucial function in enhancing human health. Since ancient times, hundreds of medicinal plants have been used to treat various diseases. Ficus religiosa (Peepal) holds a prominent position among medicinal plants. Almost every portion of this tree, including its leaves, bark, seeds, and fruits, is used to make herbal remedies. This study evaluates the nephroprotective activity of Ficus religiosa when administered Gentamicin to Wistar rodents. Twenty-four young and healthy male Wistar rats were used in the experiment, which was conducted for one week before the rodents were sacrificed at the conclusion. Gentamicin induced nephrotoxicity at a dose of 42 mgkg per day. At the conclusion of the study, biochemical parameters revealed that both 150 mgkg and 300 mgkg of Ficus religiosa extract exhibited significant nephroprotective activity.