Nephroprotective efficacy of Moringa oleifera aqueous unripe fruit extract against gentamicin-induced nephrotoxicity in wistar rats. (KEY IJP************961)

• Prashant Kumar Dhakad

Abstract

There has been a renaissance of interest in the study of medicinal plants in recent years due to their widespread application in the treatment of many human ailments. Traditional medicine employs a broad variety of herbs for their alleged ability to cure urinary issues. Many people with nephrolithiasis in India consume a decoction made from the seeds of the plant Moringa oleifera, which contains an aqueous extract of its unripe fruit. There is currently no evidence from scientific studies showing that this plant helps people with renal issues. At doses of 250 mgkg and 500 mgkg body weight i.p., the aqueous unripe fruit extract of Moringa oleifera was shown to be efficacious in both male and female rats as nephroprotection, without causing any harm. The diuretic effects of Moringa oleifera have been attributed to the plant's flavanoids, saponins, organic acids, and steroidal substances. Loss of fluid might account for the ratsdramatic weight loss; in the treated groups, urine volume rose. Rats given only gentamicin had significantly higher levels of urine creatinine, serum creatinine, blood urea, blood urea nitrogen, and kidney weights compared to control rats (p<0.01), while rats given an aqueous extract of Moringa oleifera's unripe fruit were protected from gentamicin's nephrotoxicity.